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Efficacy

Evaluation Model

Evaluation Indicator

Anti-peeling/

Anti-dandruff/

Scalp care

Inhibition of Malassezia

Bacterial growth inhibition zone, MIC

Type II 5α- reductase inhibition experiment

Inhibition rate of dihydrotestosterone (DHT) generation

Testing of cell proliferation, migration rate, and aggregation ability in DPC (dermal papilla cells)

Cell proliferation, migration rate, and aggregation ability

Induction of DPC (dermal papilla cells) injury model by dihydrotestosterone (DHT)

Expression of growth factors (VEGF, IGF, FGF, etc.) and AR

Induction of DPC (dermal papilla cells) injury model by hydrogen peroxide

Expression of growth factors (VEGF, IGF, FGF, etc.) , measurement of ROS content

Isolated hair follicles of mice

Tissue viability

Inhibition of LNCaP cell proliferation

Cell vitality

Stimulation of sebum secretion in sebaceous gland cells by dihydrotestosterone (DHT)

Lipid droplets, Expression of genes related to lipid synthesis (SREBP-1, FAS)